Protein name:
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta;IL-6R subunit beta;IL-6R-beta;IL-6RB) ;
Alternative:
Interleukin-6 signal transducer ;CDw130 ;Oncostatin-M receptor subunit alpha ;Membrane glycoprotein 130 (gp130) ;
CD:
CD130 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus IL6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST.
Function:
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
Subcellular Location:
Isoform 2
Secreted
Protein Attributes:
50:
MLTLQTWLVQ | ALFIFLTTES | TGELLDPCGY | ISPESPVVQL | HSNFTAVCVL |
100:
KEKCMDYFHV | NANYIVWKTN | HFTIPKEQYT | IINRTASSVT | FTDIASLNIQ |
150:
LTCNILTFGQ | LEQNVYGITI | ISGLPPEKPK | NLSCIVNEGK | KMRCEWDGGR |
200:
ETHLETNFTL | KSEWATHKFA | DCKAKRDTPT | SCTVDYSTVY | FVNIEVWVEA |
250:
ENALGKVTSD | HINFDPVYKV | KPNPPHNLSV | INSEELSSIL | KLTWTNPSIK |
300:
SVIILKYNIQ | YRTKDASTWS | QIPPEDTAST | RSSFTVQDLK | PFTEYVFRIR |
350:
CMKEDGKGYW | SDWSEEASGI | TYEDRPSKAP | SFWYKIDPSH | TQGYRTVQLV |
400:
WKTLPPFEAN | GKILDYEVTL | TRWKSHLQNY | TVNATKLTVN | LTNDRYLATL |
450:
TVRNLVGKSD | AAVLTIPACD | FQATHPVMDL | KAFPKDNMLW | VEWTTPRESV |
500:
KKYILEWCVL | SDKAPCITDW | QQEDGTVHRT | YLRGNLAESK | CYLITVTPVY |
550:
ADGPGSPESI | KAYLKQAPPS | KGPTVRTKKV | GKNEAVLEWD | QLPVDVQNGF |
600:
IRNYTIFYRT | IIGNETAVNV | DSSHTEYTLS | SLTSDTLYMV | RMAAYTDEGG |
650:
KDGPEFTFTT | PKFAQGEIEA | IVVPVCLAFL | LTTLLGVLFC | FNKRDLIKKH |
700:
IWPNVPDPSK | SHIAQWSPHT | PPRHNFNSKD | QMYSDGNFTD | VSVVEIEAND |
750:
KKPFPEDLKS | LDLFKKEKIN | TEGHSSGIGG | SSCMSSSRPS | ISSSDENESS |
800:
QNTSSTVQYS | TVVHSGYRHQ | VPSVQVFSRS | ESTQPLLDSE | ERPEDLQLVD |
850:
HVDGGDGILP | RQQYFKQNCS | QHESSPDISH | FERSKQVSSV | NEEDFVRLKQ |
900:
QISDHISQSC | GSGQMKMFQE | VSAADAFGPG | TEGQVERFET | VGMEAATDEG |
918:
MPKSYLPQTV | RQGGYMPQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human IL-6 receptor subunit beta
ELISA Kit for Human IL-6 receptor subunit beta
ELISA Kit for Human IL-6 receptor subunit beta
CLIA Kit for Human IL-6 receptor subunit beta
CLIA Kit for Human IL-6 receptor subunit beta
CLIA Kit for Human IL-6 receptor subunit beta
Polyclonal Antibody for Human IL-6 receptor subunit beta
Polyclonal Antibody for Human IL-6 receptor subunit beta
Polyclonal Antibody for Human IL-6 receptor subunit beta
Monoclonal Antibody for Human IL-6 receptor subunit beta
Monoclonal Antibody for Human IL-6 receptor subunit beta
Monoclonal Antibody for Human IL-6 receptor subunit beta
Protein for Human IL-6 receptor subunit beta
Protein for Human IL-6 receptor subunit beta
Protein for Human IL-6 receptor subunit beta
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
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ALTINAY S, CABALAR M, ISLER C, et al.
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